From Erie, PA:

• Merge onto I-190 N/New York State Thruway via the I-190 exit 53 to Downtown Buffalo/Niagara Falls
• Take the Niagara St/RT-266 exit 8
• Turn right at Niagara St/RT-266

From Rochester:

• Take the left fork to I-90 W/New York State Thruway W and merge onto I-90 W/New York State Thruway West
• Merge onto Kensington Expy/RT-33 W via the RT-33 W exit 51W to Buffalo
• Slight left at N Oak St
• Turn right at Genesee St
• Slight right at E Chippewa St
• Turn left at Georgia St.
• Turn right at Niagara St/RT-266

From Canada:

• Get onto the I-190 S/New York State Thruway ramp
• Take the left fork to I-190 S/I-90/Downtown Buffalo/New York State Thruway and merge onto I-190 S/New York State Thruway
• Take the Niagara St/RT-266 exit 8
• Turn right at Niagara St/RT-266